Preferred Label : IL-12-expressing HSV-1 NSC 733972;
NCIt definition : A genetically engineered, replication selective, infected cell protein (ICP) 34.5
gene-deleted, oncolytic human simplex virus type 1 (HSV-1) expressing the human immunostimulating
cytokine interleukin-12 (IL-12), with potential antineoplastic activity. Upon intratumoral
administration of HSV-1 expressing IL-12 NSC 733972, the IL-12-expressing HSV-1 preferentially
infects and replicates in tumor cells of neuronal origin causing viral-mediated tumor
cell lysis. The released virus particles, in turn, infect and replicate in neighboring
tumor cells. In addition, the IL-12-expressing HSV-1 promotes the secretion of IL-12
by the tumor cells. IL-12 promotes the activation of natural killer cells, which induces
both the secretion of interferon-gamma and a cytotoxic T-lymphocyte (CTL) response
against the tumor cells. This results in both immune-mediated tumor cell death and
further inhibition of tumor cell proliferation. Deletion of the gene encoding for
ICP34.5 imparts tumor selectivity by preventing replication in healthy cells.;
Molecule name : M032; NSC 733972;
NCI Metathesaurus CUI : CL471805;
Origin ID : C114294;
UMLS CUI : C3827095;
Semantic type(s)
- Virus [UMLS semantic type]
- concept_is_in_subset
