Preferred Label : HER2-pulsed Autologous Type-1 Polarized Dendritic Cell Vaccine;
NCIt synonyms : HER-2 pulsed DC1 Vaccine;
NCIt definition : A dendritic cell (DC)-based cancer vaccine composed of autologous, type-1 polarized
dendritic cells (DCs) pulsed with human leukocyte antigen (HLA)-A2-restricted HER-2-derived
peptides, with potential immunomodulatory and antineoplastic activities. Autologous
DCs were treated with GM-CSF, interleukin-4, interferon-gamma and bacterial lipopolysaccharide
(LPS), a toll-like receptor type 4 agonist, to produce highly polarized DCs (alphaDC1)
that are capable of producing high levels of interleukin-12p70 (IL-12p70). Upon administration,
HER2-pulsed autologous DC vaccine may stimulate a potent cytotoxic T-lymphocyte (CTL)
response against HER-2-positive tumor cells, which may result in tumor cell death
and decreased tumor growth. HER-2, a tyrosine kinase receptor for epidermal growth
factor (EGF) (also known as neu and ErbB2), is overexpressed by a variety of cancers.;
NCI Metathesaurus CUI : CL472222;
Origin ID : C114293;
UMLS CUI : C3829707;
Semantic type(s)
- concept_is_in_subset
