NCIt definition : A monoclonal antibody directed against the cell surface protein claudin 6 (CLDN6),
with potential immunostimulating and antineoplastic activities. Upon administration,
the anti-CLDN6 monoclonal antibody ASP1650 binds to CLDN-6 and may stimulate the immune
system to exert both an antibody-dependent cellular cytotoxicity (ADCC) and a complement-dependent
cytotoxicity (CDC) mediated immune response against CLDN-6-expressing tumor cells.
This may inhibit tumor cell growth. CLDN-6, a tight-junction protein and embryonic
antigen, is expressed on a variety of tumor cells but is not expressed on normal,
healthy adult cells.;
Semantic type(s)