Preferred Label : H1299 Tumor Cell Lysate Vaccine;
NCIt synonyms : H1299 Lysate Vaccine;
NCIt definition : A cell lysate derived from a lung cancer cell line, H1299, with potential immunostimulatory
and antineoplastic activities. Upon intramuscular administration, the H1299 tumor
cell lysate exposes the immune system to an undefined amount of tumor associated antigens
(TAA), particularly cancer testis antigens (CTAs), which may result in the induction
of both anti-tumoral cytotoxic T-lymphocytes (CTL) and antibody-dependent responses
against TAA-expressing cells, leading to tumor cell lysis. CTAs, such as MAGE, are
selectively expressed in a variety of cancers but are not expressed in normal, healthy
cells outside the testis.;
NCI Metathesaurus CUI : CL471792;
Origin ID : C114284;
UMLS CUI : C3829914;
Semantic type(s)
- concept_is_in_subset
