Preferred Label : Anatabine;
NCIt synonyms : (-)-Anatabine; 1,2,3,6-Tetrahydro-2,3'-bipyridine; (S)-1,2,3,6-Tetrahydro-2,3'-bipyridine; 2,3'-Bipyridine, 1,2,3,6-tetrahydro-, (S)- (9CI);
NCIt definition : An alkaloid found in low concentrations in plants in the Solanaceae family, which
includes tobacco and tomato plants, with potential nicotine mimetic and anti-inflammatory
activities. Following oral administration, anatabine may mimic the neurological effects
of nicotine exposure. This agent may not have the addictive properties of nicotine;
therefore, it may be appropriate for use in treating nicotine withdrawal symptoms
during smoking cessation. Anatabine may also exert its anti-inflammatory effect by
the inhibition of the signal transducer and activator of transcription 3 (STAT3) which
then prevents the activation of the nuclear factor kappa B (NF-kB), which is a key
regulator of proinflammatory cytokine release. Urine concentrations of anatabine can
be used to assess the extent of tobacco use.;
UNII : 5PP654XB7D;
CAS number : 581-49-7;
Origin ID : C114277;
UMLS CUI : C0051816;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
