Mitomycin C Analog KW-2149

Preferred Label : Mitomycin C Analog KW-2149;

NCIt synonyms : 7-N-(2-((2-(gamma-L-Glutamylamino)ethyl)dithio)ethyl)mitomycin C;

NCIt related terms : KW-2149;

NCIt definition : A semisynthetic water-soluble disulfide derivative of the antineoplastic antibiotic mitomycin C. Activated by serum and glutathione, KW-2149 causes interstrand DNA cross-links and DNA-protein cross-links, resulting in single-strand DNA breaks and inhibition of DNA synthesis. (NCI04);

UNII : AK8DKI0KMN;

CAS number : 118359-59-4;

Molecule name : KT6149; KW 2149;

Details

Origin ID

C1140;

UMLS CUI

C0064443;

Currated CISMeF NLP mapping
- KW 2149 [MeSH concept]
- KW 2149 [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- 7-N-(2-((2-(gamma-glutamylamino)ethyl)dithio)ethyl)mitomycin C [MeSH concept]
- KW 2149 [MeSH Supplementary Concept]
- KW 2149 [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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