Preferred Label : Sulforaphane-cyclodextrin Complex;
NCIt synonyms : Stabilized Sulforaphane;
NCIt definition : An orally available, stable powder formulation composed of sulforaphane, a naturally-occurring
phytochemical belonging to the class of isothiocyanates, encapsulated within alpha-cyclodextrin,
with chemopreventive activity. Upon administration of sulforaphane/alpha-cyclodextrin
complex SFX-01, sulforaphane activates the transcription factor NF-E2-related factor
2 (Nrf2; NFE2L2), a member of the basic leucine zipper family, which binds to and
activates antioxidant-response elements (AREs). Subsequently, activated AREs mediate
the transcription of various cytoprotective genes and antioxidant enzymes, particularly
phase II detoxification enzymes, such as glutathione-S-transferase and quinone oxidoreductase,
resulting in the detoxification of highly reactive carcinogens. Cyclodextrin is able
to prevent sulforaphane's rapid breakdown, which improves its stability and half-life.;
Drug name : Sulforadex;
Molecule name : SFX-01;
NCI Metathesaurus CUI : CL471785;
Origin ID : C113804;
UMLS CUI : C3827900;
Semantic type(s)
- concept_is_in_subset
