Preferred Label : Autologous Mesenchymal Stem Cells Apceth_101;
NCIt synonyms : Agenmestencel-T; Autologous MSC_Apceth_101;
NCIt definition : Human autologous mesenchymal stem cells (MSCs) harvested from the bone marrow of a
patient and genetically modified with a self-inactivating retroviral vector expressing
the suicide gene herpes simplex virus thymidine kinase (HSV-TK), that can be used
to activate synthetic acyclic guanosine analogues when co-administered. Upon intravenous
administration of autologous mesenchymal stem cells apceth_101, the cells are actively
recruited to the tumor stroma, differentiate into more mature mesenchymal cells, and
become part of the tumor microenvironment. When a synthetic acyclic guanosine analogue,
such as ganciclovir, is co-administered, the HSV-TK within the HSV-TK-transduced MSCs
will monophosphorylate this prodrug. Subsequently the monophosphate form is further
converted to the diphosphate form and then to its active triphosphate form by cellular
kinases. The active form of ganciclovir kills the HSV-TK-transduced MSCs and leads
to a bystander effect, which eliminates neighboring cancer cells. Therefore, synthetic
acyclic guanosine analogues are activated only at the tumor site, which increases
their local efficacy and reduces systemic toxicity.;
NCI Metathesaurus CUI : CL471784;
Origin ID : C113803;
UMLS CUI : C3831434;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
