Preferred Label : Lutetium Lu 177 DOTA-biotin;
NCIt synonyms : 177Lu-ST2210; [177Lu]DOTA-biotin;
NCIt related terms : CABIOTRAXETAN LUTETIUM LU-177;
NCIt definition : A radioconjugate of biotin conjugated with the bifunctional, macrocyclic chelating
agent tetra-azacyclododecanetetra-acetic acid (DOTA) and labeled with the beta-emitting
isotope lutetium Lu 177 (Lu-177) that can be used for radioimmunotherapeutic purposes.
Lutetium Lu 177 DOTA-biotin could be used in pre-targeting radioimmunotherapy, which
pretreats the lesion with oxidized avidin that binds to protein amino groups on cells.
As avidin binds to biotin, the radioisotope can be selectively delivered to cancer
cells leading to tumor cell eradication.;
UNII : 5U8L0A8I80;
NCI Metathesaurus CUI : CL471782;
Origin ID : C113801;
UMLS CUI : C3829241;
Semantic type(s)
- concept_is_in_subset
