Preferred Label : Extended-release Onapristone;
NCIt synonyms : ER Onapristone;
NCIt definition : An extended-release (ER) formulation of onapristone, an orally bioavailable progesterone
receptor (PR) antagonist, with antineoplastic activity. Onapristone binds to the PR
and inhibits both PR activation and the associated expression of PR-responsive genes.
This may inhibit PR-mediated proliferative effects in cancer cells overexpressing
PR. PR is expressed on certain cancer cell types and plays a key role in proliferation
and survival.;
NCI Metathesaurus CUI : CL471779;
Origin ID : C113797;
UMLS CUI : C3830285;
Semantic type(s)
- concept_is_in_subset
