Preferred Label : Anti-von Willebrand Factor Nanobody;
NCIt synonyms : Anti-vWf Nanobody;
NCIt definition : A humanized, bivalent anti-von Willebrand factor (VWF) nanobody with potential anti-platelet
activity. Anti-von Willebrand factor nanobody specifically binds to the A1 domain
of the VWF molecule, thereby inhibiting and neutralizing VWF activity. This prevents
the interaction of VWF with the platelet glycoprotein (Gp)Ib-IX-V receptor and prevents
VWF-mediated platelet aggregation. VWF is a glycoprotein and plays a key role in blood
coagulation. Increased VWF, which is seen in a number of diseases, is associated with
an increased risk in thrombosis. The nanobody formulation allows for rapid distribution,
onset of action and clearance. The nanobody is based on the smallest functional fragments
of single-chain antibodies that naturally occur in the Camelidae family.;
NCI Metathesaurus CUI : CL471778;
PubMed : 19479665;
Origin ID : C113796;
UMLS CUI : C3831509;
Semantic type(s)
- concept_is_in_subset
