Preferred Label : PH20 Hyaluronidase-expressing Adenovirus VCN-01;
NCIt synonyms : Genetically Modified Adenovirus-encoding Human PH20 Hyaluronidase VCN-01;
NCIt definition : An oncolytic, replication-competent adenovirus encoding the human glycosylphosphatidylinositol-anchored
enzyme PH20 hyaluronidase with potential antitumor activity. After intratumoral administration,
PH20 hyaluronidase-expressing adenovirus VCN-01 selectively replicates in tumor cells,
which may both cause oncolytic virus-induced cell death and induce the infection of
adjacent tumor cells. In addition, the virus expresses hyaluronidase, which hydrolyzes
and degrades the hyaluronic acid (HA) that coats tumor cells. The degradation of HA
may result in a decrease for both the viscosity of the interstitial space and the
tumor's interstitial fluid pressure (IFP). This increases viral spread and may result
in the inhibition of tumor cell growth. In addition, HA degradation facilitates the
penetration of chemotherapeutic agents into the tumor. HA is a glycosaminoglycan found
in the extracellular matrix (ECM) and is frequently overproduced by various tumor
cell types. The presence of HA in tumors correlates with increases in tumor cell growth,
metastatic potential, tumor progression and resistance to chemotherapeutic agents.;
Molecule name : VCN-01;
NCI Metathesaurus CUI : CL471771;
Origin ID : C113790;
UMLS CUI : C3827070;
Semantic type(s)
- concept_is_in_subset
