Preferred Label : Anti-CD98 Monoclonal Antibody IGN523;
NCIt related terms : IGN-523;
NCIt definition : A humanized, monoclonal antibody targeting the CD98 (gp125) antigen, with potential
immunomodulatory and antineoplastic activities. Upon intravenous administration, IGN523
binds to CD98 expressed on the tumor cell surface and elicits both natural killer
(NK)-cell mediated antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent
cytotoxicity towards CD98-expressing tumor cells. In addition, IGN523 inhibits essential
amino acid uptake by rapidly proliferating tumor cells. CD98, a type II transmembrane
glycoprotein, is involved in both integrin signaling and amino acid transport processes;
it is overexpressed in certain cancer cells and plays a key role in the proliferation,
survival and metastasis of tumor cells.;
UNII : 7OI79TB6KN;
CAS number : 2206820-08-6;
Molecule name : IGN523;
NCI Metathesaurus CUI : CL458372;
Origin ID : C113659;
UMLS CUI : C3827114;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
