Preferred Label : Carboxylesterase-expressing Allogeneic Neural Stem Cells;
NCIt synonyms : CE-secreting Allogeneic NSCs; hCE1m6-NSC;
NCIt definition : A preparation of allogeneic neural stem cells (NSC), derived from a human fetal cell
line, that are adenovirally-transduced to express a modified form of the human enzyme
carboxylesterase (CE) hCE1m6, with potential adjuvant activity. Upon intracranial
administration, NSCs localize to tumor sites, due to their tumor-trophic nature, and
transiently express hCE1m6. Intravenous co-administration of the prodrug irinotecan
allows for the selective conversion by hCE1m6 to its active metabolite and topoisomerase
I inhibitor, SN-38, in the vicinity of tumor sites. This leads to a local anti-neoplastic
effect and causes reduced toxicity and increased therapeutic efficacy of irinotecan.
Since NSCs freely cross the blood-brain barrier, these cells can also be intravenously
administered to target brain tumor cells. hCE1m6 shows increased activity as compared
to unmodified human CE.;
NCI Metathesaurus CUI : CL458370;
Origin ID : C113657;
UMLS CUI : C3826997;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
