Preferred Label : Midazolam-containing Buccal Liquid;
NCIt definition : An oromucosal solution containing the maleate salt form of midazolam, a short-acting
benzodiazepine derivative, with anxiolytic, hypnotic, anticonvulsant and sedative
activities. Upon administration of the solution into the buccal cavity, midazolam
exerts its effect by binding to the benzodiazepine receptor at the gamma-aminobutyric
acid (GABA) receptor-chloride ionophore complex in the central nervous system (CNS).
This leads to an increase in the permeability of chloride channels, membrane hyperpolarization
and enhances the inhibitory effect of GABA in the CNS. Midazolam may also interfere
with the reuptake of GABA, thereby causing accumulation of GABA in the synaptic cleft.
The oromucosal formulation facilitates administration to patients that are unable
to swallow. The ethanol in this formulation improves the buccal absorption of midazolam.;
Drug name : Epistatus;
NCI Metathesaurus CUI : CL458367;
Origin ID : C113654;
UMLS CUI : C3829073;
Semantic type(s)
- concept_is_in_subset
