Preferred Label : IVAC Mutanome Vaccine;
NCIt definition : An individualized, poly-neo-epitopic encoding, ribonucleic acid (RNA)-based cancer
vaccine that targets a variety of patient-specific, immunogenic mutant epitopes, with
potential immunostimulatory and antineoplastic activities. Upon intranodal administration,
the RNA in the individualized mutanome vaccine is translated by antigen presenting
cells (APCs) and the expressed protein is presented via major histocompatibility complex
(MHC) molecules on the surface of the APCs. This leads to an induction of both cytotoxic
T-lymphocyte (CTL) and memory T-cell immune responses against the patient-specific
neoantigens.;
NCI Metathesaurus CUI : CL458363;
Origin ID : C113650;
UMLS CUI : C3829487;
Semantic type(s)
- concept_is_in_subset
