Preferred Label : Alpha-1,3-galactosyltransferase-expressing Allogeneic Renal Cell Carcinoma Vaccine;
NCIt synonyms : HAR;
NCIt definition : An allogeneic renal cell cancer (RCC) vaccine composed of cell line-derived RCCs that
are genetically engineered to express the murine alpha-1,3-galactosyltransferase (GalT),
with potential immunostimulatory and antineoplastic activities. Not naturally occurring
in humans, GalT catalyzes the expression of foreign alpha-1,3-galactosyl (alpha-gal)
carbohydrate epitopes on the cell membranes of the allogeneic RCCs present in the
vaccine. This induces a hyperacute rejection reaction involving pre-existing human
anti-alpha-gal antibodies, which bind to the foreign alpha-gal epitopes expressed
by the allogeneic RCCs. This results in complement-mediated cytotoxicity (CMC) and
antibody-dependent cell-mediated cytotoxicity (ADCC) towards endogenous RCCs with
unmodified carbohydrate epitopes.;
Drug name : HyperAcute Renal;
NCI Metathesaurus CUI : CL458360;
PubMed : 15161001;
Origin ID : C113647;
UMLS CUI : C3815169;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
