Preferred Label : Omaveloxolone;
NCIt synonyms : Propanamide, N-(2-cyano-3,12-dioxo-28-noroleana-1,9(11)-dien-17-yl)-2,2-difluoro-;
NCIt definition : A member of the synthetic oleanane triterpenoid class of compounds and an activator
of nuclear factor erythroid 2 [NF-E2]-related factor 2 (Nrf2, Nfe2l2), with potential
chemopreventive activity. Upon administration, omaveloxolone activates the cytoprotective
transcription factor Nrf2. In turn, Nrf2 translocates to the nucleus, dimerizes with
a small Maf protein (sMaf), and binds to the antioxidant response element (ARE). This
induces the expression of a number of cytoprotective genes, including NAD(P)H quinone
oxidoreductase 1 (NQO1), sulfiredoxin 1 (Srxn1), heme oxygenase-1 (HO1, HMOX1), superoxide
dismutase 1 (SOD1), gamma-glutamylcysteine synthetase (gamma-GCS), thioredoxin reductase-1
(TXNRD1), glutathione S-transferase (GST), glutamate-cysteine ligase catalytic subunit
(Gclc) and glutamate-cysteine ligase regulatory subunit (Gclm), and increases the
synthesis of the antioxidant glutathione (GSH). Nrf2, a leucine zipper transcription
factor, plays a key role in the maintenance of redox balance and cytoprotection against
oxidative stress.;
UNII : G69Z98951Q;
InChIKey : RJCWBNBKOKFWNY-IDPLTSGASA-N;
CAS number : 1474034-05-3;
Molecule name : RTA 408; RTA-408;
Origin ID : C113443;
UMLS CUI : C4519135;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
