Preferred Label : Copper Cu 62-ATSM;
NCIt synonyms : 62Cu-ATSM;
NCIt definition : A radioconjugate consisting of a lipophilic, neutral, bioreductive copper-bis(thiosemicarbazone)
complex, copper-diacetyl-bis(N4-methylthiosemicarbazone) (Cu-ATSM), labeled with the
beta-emitting radioisotope copper Cu 62, with hypoxia-selective and positron emitting
tomography (PET) radioimaging activities. With a high membrane permeability and low
reduction potential, copper Cu 62-ATSM easily enters cells. This agent can only be
reduced by mitochondria found in hypoxic cells with abnormally high electron concentrations.
This chemical reaction traps Cu 62-ATSM in the cell, which allows for the selective
accumulation of this agent in hypoxic cells compared to normoxic cells. The extent
of copper Cu 62-ATSM retention in tissue is inversely related to the state of tissue
oxygenation allowing the quantitation of tissue hypoxia with PET. This provides information
about diagnosis, prognosis, treatment options and outcomes for certain cancers. The
short half-life of copper Cu 62 (9.7 minutes) reduces the amount of radiation a patient
is subjected to and allows for several imaging studies to be performed. Hypoxic tumors
are associated with increased malignancy and resistance to radiation and chemotherapy.;
NCI Metathesaurus CUI : CL458235;
Origin ID : C113441;
UMLS CUI : C3827042;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
