Preferred Label : Copper Cu 62-PTSM;
NCIt synonyms : 62Cu-PTSM;
NCIt definition : A radioconjugate consisting of a lipophilic, bioreductive copper(II)bis(thiosemicarbazone)
complex, copper-pyruvaldehyde-bis(N4-methylthiosemicarbazone) (Cu-PTSM), linked to
the beta-emitting, radioisotope copper Cu 62, with potential perfusion and positron
emitting tomography (PET) tumor imaging activities. Upon injection, the distribution
of copper Cu 62-PTSM correlates with blood flow. This agent's high membrane permeability
allows for rapid diffusion into cells. Once it enters the cell, 62Cu-PTSM is then
reduced by the mitochondria, which prevents diffusion of the agent out of the cell.
Upon PET imaging, tumor blood flow can be visualized and tumor perfusion can be assessed.
Compared with other copper radionuclides, the short half-life of copper Cu 62 (9.7
minutes) reduces the amount of radiation a patient is subjected to and allows for
several imaging studies to be performed. PTSM lacks selectivity for hypoxic cells.;
Origin ID : C113440;
UMLS CUI : C3827041;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
