Preferred Label : Dusquetide;
NCIt synonyms : L-Alaninamide, L-arginyl-L-isoleucyl-L-valyl-L-prolyl-;
NCIt related terms : Innate Defense Regulator SGX942;
NCIt definition : A synthetic, 5-amino acid peptide and Innate Defense Regulator (IDR), with immunomodulating,
anti-inflammatory, anti-infective and anti-mucositis activities. Upon intravenous
administration, dusquetide binds to the ZZ domain of sequestosome-1, also called p62,
and activates regulatory signaling transduction pathways involved in the modulation
of the innate immune system, such as those mediated by mitogen-activated protein kinase
(MAPK) p38 and CCAAT-enhancer-binding protein. This agent promotes monocyte and macrophage
recruitment to, and accelerates healing in damaged and infected tissue; it suppresses
inflammation through the regulation of the expression of multiple cytokines. This
agent may prevent or decrease chemo- or radiotherapy-induced mucositis as well as
other types of infection. p62, an intracellular adaptor protein that functions downstream
of certain signaling receptors, plays a key role in the activation of the innate immune
system.;
UNII : IKX7W49NLN;
CAS number : 931395-42-5;
Molecule name : SGX942; IMX 942;
NCI Metathesaurus CUI : CL458231;
Origin ID : C113437;
UMLS CUI : C4505876;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
