Preferred Label : Wnt-5a Mimic Hexapeptide Foxy-5;
NCIt related terms : FOXY-5;
NCIt definition : A formylated, six amino acid, Wnt5a-derived peptide and wnt-5a mimetic with potential
anti-metastatic activity. Upon intravenous administration, Wnt-5a mimic hexapeptide
foxy-5 binds to and activates the wnt-5a receptors, Frizzled-2 and -5, which activates
wnt-5a-mediated signaling. Increased wnt-5a signaling may inhibit endothelial tumor
cell migration and invasion. This may decrease metastasis of susceptible tumor cells.
However, foxy-5 does not affect tumor cell proliferation or apoptosis. Foxy-5 lacks
a heparan sulfate-binding domain and contains a formyl group on its NH2-terminal methionine
residue which decreases in vivo degradation. Decreased expression of wnt-5a protein
is associated with increased motility of certain tumor cell types.;
UNII : CBZ9UL0ARB;
CAS number : 881188-51-8;
Molecule name : Foxy-5;
NCI Metathesaurus CUI : CL458229;
Origin ID : C113435;
UMLS CUI : C3827126;
Semantic type(s)
- concept_is_in_subset
