Preferred Label : NY-ESO-1/GLA-SE Vaccine ID-G305;
NCIt definition : A cancer vaccine composed of a recombinant form of the tumor antigen NY-ESO-1 and
glucopyranosyl lipid adjuvant (GLA)-stable emulsion (GLA-SE), with potential antineoplastic
and immunomodulating activities. Upon intramuscular injection, the adjuvant portion
of the NY-ESO-1/GLA-SE vaccine ID-G30 binds to toll-like receptor subtype 4 (TLR-4)
expressed on dendritic cells (DCs), monocytes, macrophages and B cells. The activated
DCs present the NY-ESO-1 antigen to Th1 CD4 T-lymphocytes. This leads to the induction
of cytotoxic T lymphocytes (CTLs) and the killing of NY-ESO-1-expressing tumor cells.
This vaccine also induces specific antibody responses and increases the production
of inflammatory cytokines.;
Molecule name : IDC-G305; ID-G305;
NCI Metathesaurus CUI : CL458226;
Origin ID : C113432;
UMLS CUI : C3827115;
Semantic type(s)
- concept_is_in_subset
- has_target
