Preferred Label : Pegilodecakin;
NCIt synonyms : PEG-rHuIL-10 AM0010;
NCIt definition : A covalent conjugate of recombinant human interleukin-10 (IL-10) and polyethylene
glycol (PEG), with potential anti-fibrotic, anti-inflammatory, immunomodulating and
antineoplastic activities. Upon subcutaneous administration, pegilodecakin may activate
cell-mediated immunity against cancer cells by stimulating the differentiation and
expansion of tumor specific cytotoxic CD8 T cells. This agent may also lower serum
cholesterol levels and reduce atherosclerotic plaques by inhibiting the synthesis
of pro-inflammatory cytokines, such as Interferon-gamma, IL-2, IL-3, TNF-alpha, and
GM-CSF. The PEG moiety inhibits proteolytic breakdown and clearance of AM0010, which
prolongs its half-life, extends the duration of its therapeutic effects and allows
less frequent dosing.;
UNII : 5Z9850I25F;
CAS number : 1966111-35-2;
Molecule name : AM-0010;
NCI Metathesaurus CUI : CL458142;
Origin ID : C113295;
UMLS CUI : C4760801;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- AM0010 [MeSH Supplementary Concept]
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
