Preferred Label : P-p68 Inhibitor RX-5902;
NCIt related terms : SUPINOXIN;
NCIt definition : An orally bioavailable small molecule inhibitor of phosphorylated-p68 RNA helicase
(P-p68), with potential anti-proliferative and antineoplastic activity. Upon oral
administration, P-p68 inhibitor RX-5902 may both inhibit the activity of the anti-apoptotic
B-cell lymphoma 2 (Bcl-2) protein and facilitate the induction of cyclin-dependent
kinase inhibitor 1 (p21). This may prevent G2/M cell cycle progression and lead to
growth inhibition in tumor cells. P-p68 is overexpressed in various types of solid
tumors but absent in normal tissues, and plays a role in tumor progression and metastasis.
p21 is a potent cyclin-dependent kinase inhibitor which regulates cell cycle progression
and mediates both growth arrest and cellular senescence.;
UNII : ZU8OM8V5WF;
CAS number : 888478-45-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 888478-45-3
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G-SRS /a ;
Drug name : Supinoxin;
Molecule name : RX-5902;
Origin ID : C113293;
UMLS CUI : C3827081;
Semantic type(s)
- UMLS correspondences (same concept)
- RX-5902 [MeSH Supplementary Concept]
- concept_is_in_subset
