Preferred Label : DACH-Platin Micelle NC-4016;
NCIt synonyms : Diaminocyclohexane Platinum Micelle NC-4016; DACH-Pt/m NC-4016;
NCIt definition : Polymeric micellar nanoparticles containing diaminocyclohexane platinum (DACH-platin
or DACH-Pt) with potential antineoplastic activity. DACH-platin micelle NC-4016 is
prepared through the formation of a polymer-metal complex between DACH-platin and
the polyethylene glycol-poly (glutamic acid) block copolymer, PEG-P(Glu). DACH-platin,
an active metabolite of the platinum-based antineoplastic agent oxaliplatin, is highly
hydrophobic and toxic when administered systemically. The use of polymeric micelles
incorporating DACH-platin may both increase cell permeability and enhance the retention
of the agent. This allows an extended half-life in the blood circulation and a selective
and high accumulation of DACH-platin at tumor sites. This results in increased anticancer
efficacy while reducing side effects due to DACH-platin toxicity. Upon intravenous
administration and internalization by tumor cells, DACH-platin binds to and causes
both inter- and intra-strand cross-links in DNA, forming platinum adducts and triggering
tumor cell apoptosis.;
Molecule name : NC-4016;
NCI Metathesaurus CUI : CL455246;
Origin ID : C113175;
UMLS CUI : C3827098;
Semantic type(s)
- UMLS correspondences (same concept)
- NC-4016 [MeSH Supplementary Concept]
- concept_is_in_subset
