NCIt synonyms : 273-666-Neuraminidase [273-Methionine] (Actinomyces viscosus Clone DAS181) Fusion
Protein With 125-145-Preproamphiregulin (Human); Recombinant Cell-Surface Anchored Sialidase DAS181;
NCIt definition : A recombinant sialidase fusion protein composed of a sialidase catalytic domain derived
from Actinomyces viscosus, a constituent of the normal oral and gastrointestinal flora
in humans, fused to a cell surface-anchoring domain, with potential anti-viral activity.
Following administration by oral inhalation, oplunofusp proteolytically removes sialic
acid from the airway epithelium, which inhibits viral binding to and internalization
by cells of the respiratory epithelium and prevents viral replication. The cell surface
anchoring-domain of this agent may increase retention time and drug potency. Sialic
acids in the respiratory tract are used by influenza and parainfluenza viruses to
invade airway epithelial cells.;
Currated CISMeF NLP mapping