BET Inhibitor RO6870810

Preferred Label : BET Inhibitor RO6870810;

NCIt synonyms : Bromodomain and Extra-Terminal Protein Inhibitor RO6870810;

NCIt related terms : RO-6870810;

NCIt definition : A small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins with potential antineoplastic activity. Upon administration, the BET inhibitor RO6870810 binds to the acetylated lysine recognition motifs found in the bromodomain of BET proteins, which prevents the interaction between BET proteins and acetylated histones. This interaction disrupts chromatin remodeling and gene expression. Prevention of the expression of certain growth-promoting genes may lead to an inhibition of tumor cell growth. Characterized by a tandem repeat of bromodomains at the N-terminus, BET proteins, comprised of BRD2, BRD3, BRD4 and BRDT, are transcriptional regulators that play an important role during cellular development and growth.;

UNII : TA3QN7788D;

InChIKey : PKQXLRYFPSZKDU-QFIPXVFZSA-N;

CAS number : 1349719-98-7;

Molecule name : RO6870810; TEN-010; RG 6146; RG6146; TEN 010;

NCI Metathesaurus CUI : CL454674;

Details

Origin ID

C112500;

UMLS CUI

C3827054;

Currated CISMeF NLP mapping
- RO6870810 [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- RO6870810 [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Bromodomain Testis-Specific Protein [NCIt concept]
- Bromodomain-Containing Protein 2 [NCIt concept]
- Bromodomain-Containing Protein 3 [NCIt concept]
- Bromodomain-Containing Protein 4 [NCIt concept]

Keyword's position in hierarchy(ies) :

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