NCIt definition : A recombinant therapeutic agent which is chemically identical to or similar to the
endogenous glycoprotein cytokine hepatocyte growth factor (HGF), which is produced
by the liver and the pancreas. Endogenous HGF synthesis is stimulated by injuries
affecting liver tissues. This agent, a potent angiogenic and neurotrophic factor and
a multifunctional cytokine that acts as a mitogen, motogen and a morphogen, is important
for organogenesis and tissue regeneration. Therapeutic HGF has been shown to attenuate
brain ischemic injury in animal models through angiogenic and neuroprotective actions.
(NCI04);