Preferred Label : Anti-CD19-CAR-CD3zeta-4-1BB-Expressing Allogenic Natural Killer Cells;
NCIt synonyms : Anti-CD19-CAR-CD3zeta-4-1BB-Expressing Donor NK Cells; Anti-CD19-CAR-CD3zeta-4-1BB-Expressing Donor Natural Killer Cells; Anti-CD19-CAR-CD3zeta-4-1BB-Expressing NK Cells; Anti-CD19-CAR-CD3zeta-4-1BB-Expressing Allogenic NK Cells; Anti-CD19-CAR-CD3zeta-4-1BB-Expressing Natural Killer Cells; Anti-CD19 Redirected NK Cells;
NCIt definition : Allogeneic natural killer (NK) cells transduced with an mRNA expressing a chimeric
antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment)
and the zeta chain of the TCR/CD3 complex (CD3-zeta), coupled to the signaling domain
of 4-1BB (CD137), with potential immunomodulating and antineoplastic activities. NK
cells from haploidentical donors are expanded in culture and electroporated with the
CAR mRNA. Upon transfusion of the transduced cultured cells, CD19CAR-CD3zeta-4-1BB-expressing
allogeneic NK cells bind to and induce selective cytotoxicity in CD19-expressing tumor
cells. The 4-1BB co-stimulatory molecule signaling domain enhances activation and
signaling after recognition of CD19. Its inclusion may also increase antitumor activity,
when compared to the inclusion of the CD3-zeta chain alone. CD19 antigen is a B-cell
specific cell surface antigen expressed in all B-cell lineage malignancies.;
Molecule name : NKCARCD19;
NCI Metathesaurus CUI : CL454390;
Origin ID : C112179;
UMLS CUI : C3827096;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
