Preferred Label : Neoantigen-based Melanoma-Poly-ICLC Vaccine;
NCIt synonyms : NeoVax Melanoma Vaccine;
NCIt definition : A peptide-based melanoma cancer vaccine consisting of neoantigens and peptides derived
from patient-specific melanoma immunogenic epitopes, combined with the immunostimulant
poly-ICLC with potential immunomodulating and antineoplastic activities. Vaccination
with the neoantigen-based melanoma vaccine stimulates the host immune system to mount
a cytotoxic T lymphocyte (CTL) response against tumor cells expressing the neoantigens,
which results in tumor cell lysis. The adjuvant poly-ICLC, composed of double-stranded
RNA molecules of polyinosinic-polycytidylic acid stabilized with poly L-lysine in
carboxymethylcellulose, is a ligand for toll-like receptor-3 (TLR3) and induces the
release of cytokines which may help to boost the immune response against the selected
neoantigens.;
NCI Metathesaurus CUI : CL454292;
Origin ID : C112003;
UMLS CUI : C3828839;
Semantic type(s)
- concept_is_in_subset
