Preferred Label : Cebranopadol;
NCIt synonyms : Spiro[cyclohexane-1,1'(3'H)-pyrano[3,4-b]indol]-4-amine, 6'-fluoro-4',9'-dihydro-N,N-dimethyl-4-phenyl-,
(1alpha,4beta)-;
NCIt definition : An orally available benzenoid that acts as an opioid peptide receptor agonist for
the nociceptin/orphanin FQ peptide receptor (opioid receptor like -1; OPRL1; ORL-1;
NOP; kappa-type 3 opioid receptor) and the classical opioid receptors, mu, delta and
kappa, with potential anti-nociceptive activity. Upon oral administration, cebranopadol
binds to NOP and the mu, delta and kappa opioid receptors, which enhances NOP- and
opioid receptor-mediated signaling, interferes with the sensation of pain and results
in an analgesic effect. NOP, a member of the opioid receptor family, and its endogenous
ligand nociceptin play key roles in the regulation of various brain activities including
pain, and some inflammatory and immune responses.;
UNII : 7GDW9S3GN3;
InChIKey : CSMVOZKEWSOFER-RQNOJGIXSA-N;
CAS number : 863513-91-1;
Molecule name : GRT-6005; GRT 6005;
Origin ID : C112002;
UMLS CUI : C3827125;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
