Preferred Label : Live-attenuated Listeria monocytogenes-encoding EGFRvIII-NY-ESO-1 Vaccine ADU-623;
NCIt definition : A live-attenuated, double-deleted strain of the Gram-positive bacterium Listeria monocytogenes
(Lm) encoding a mutant form of the tumor associated antigens, epidermal growth factor
receptor (EGFRvIII) and the cancer/testis antigen NY-ESO-1, with potential immunostimulatory
and antineoplastic activities. Upon intravenous administration, live-attenuated Listeria
monocytogenes encoding EGFRvIII-NY-ESO-1 vaccine targets dendritic cells and expresses
EGFRvIII and NY-ESO-1. This promotes both a potent innate immune response and an adaptive
immune response involving the recruitment and activation of T lymphocytes against
EGFRvIII and NY-ESO-1-expressing tumor cells, which results in tumor cell lysis.;
Molecule name : ADU-623;
NCI Metathesaurus CUI : CL454287;
Origin ID : C111998;
UMLS CUI : C3827170;
Semantic type(s)
- concept_is_in_subset
