Preferred Label : Anti-SLITRK6 Monoclonal Antibody-MMAE Conjugate AGS15E;
Obsolete resource : true;
NCIt synonyms : Anti-SLITRK6 Antibody-drug Conjugate AGS15E; Anti-SLITRK6 ADC AGS15E;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against
SLIT and NTRK-like protein 6 (SLITRK6), covalently linked to the cytotoxic agent monomethyl
auristatin E (MMAE), an auristatin derivative and a potent inhibitor of microtubule
polymerization, with potential antineoplastic activity. Upon intravenous administration,
the monoclonal antibody moiety of AGS15E binds to SLITRK6 expressed on tumor cells,
which facilitates both AGS15E internalization and the intracellular delivery of MMAE.
Upon cleavage, MMAE binds to tubulin and inhibits its polymerization, which results
in G2/M phase arrest and tumor cell apoptosis. SLITRK6, a member of the Slitrk family
of leucine-rich repeat (LRR) neuronal transmembrane proteins, is minimally expressed
in normal tissue but overexpressed in a variety of cancers, including bladder cancer,
some forms of lung cancer, breast cancer and glioblastoma.;
NCIt note : See 'Sirtratumab Vedotin(C152370)';
Concept status : Retired_Concept;
Molecule name : ASG-15ME; AGS15E;
NCI Metathesaurus CUI : CL454284;
Origin ID : C111995;
UMLS CUI : C3827160;
See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
