Preferred Label : Autologous GM-CSF-secreting Lethally Irradiated Colorectal Cancer Cell Vaccine;
NCIt synonyms : GVAX Colorectal Cancer Vaccine;
NCIt definition : A lethally irradiated, autologous colorectal cancer vaccine consisting of patient-specific
colorectal cancer cells genetically modified to secrete the cytokine granulocyte-macrophage
colony stimulating factor (GM-CSF), with potential immunostimulating and antineoplastic
activities. Upon vaccination, the autologous GM-CSF-secreting lethally irradiated
colorectal cancer cell vaccine releases GM-CSF. In turn, GM-CSF may increase the body's
immune response against tumor cells by promoting the maturation and activation of
dendritic cells (DCs), and enhancing tumor-specific antigen presentation to both B-
and T-cells, which leads to better recognition of tumors by the immune system. In
addition, GM-CSF promotes antibody-dependent cellular cytotoxicity (ADCC), and increases
interleukin-2-mediated lymphokine-activated killer cell function.;
NCI Metathesaurus CUI : CL454280;
Origin ID : C111991;
UMLS CUI : C3831437;
Semantic type(s)
- concept_is_in_subset
