Preferred Label : CMVpp65/gB Plasmid Vaccine ASP0113;
NCIt synonyms : TransVax;
NCIt definition : A poloxamer-formulated, bivalent DNA vaccine containing two plasmids encoding both
the human cytomegaloviral (CMV) tegument phosphoprotein 65 (pp65), a major internal
matrix protein, and glycoprotein B (gB), an important CMV component responsible for
attachment and entry into cells, with potential immunostimulatory properties. Upon
intramuscular injection of CMVpp65/gB plasmid vaccine ASP0113, the expressed proteins
may activate the immune system to mount both cellular and humoral immune responses
against CMV-positive cells. This results in cell lysis of CMV-infected cells and prevents
both viral replication and the development of CMV disease. This vaccine also provides
active immunization and protective immunity against CMV infection in CMV-negative
patients exposed to infected donor cells or tissues in transplant recipients. CMV
infection can cause serious complications in patients receiving either allogeneic
hematopoietic cell transplants (HCT) or solid organ transplants. The poloxamer-based
delivery system enhances DNA delivery.;
Molecule name : ASP0113;
NCI Metathesaurus CUI : CL454235;
Origin ID : C111903;
UMLS CUI : C3827159;
Semantic type(s)
- concept_is_in_subset
- has_target
