Preferred Label : Autologous Melanoma Lysate/NY-ESO-1-pulsed Autologous Dendritic Cell Vaccine;
NCIt definition : A cell-based cancer vaccine composed of autologous dendritic cells (DCs) pulsed with
both a lysate from autologous melanoma cells containing tumor associated antigens
(TAAs) and a synthetic peptide derived from the tumor associated antigen human cancer-testis
antigen NY-ESO-1, with potential immunostimulatory and antineoplastic activities.
Upon administration, autologous melanoma lysate/NY-ESO-1-pulsed autologous DC vaccine
may stimulate the immune system to mount anti-tumoral cytotoxic T lymphocyte (CTL)
and antibody-mediated immune responses against melanoma cells, which may result in
melanoma cell lysis. NY-ESO-1 is expressed in normal testes and on the surfaces of
various tumor cells, and plays a key role in tumor cell proliferation and survival.;
NCI Metathesaurus CUI : CL454232;
Origin ID : C111900;
UMLS CUI : C3831435;
Semantic type(s)
- concept_is_in_subset
