NCIt definition : A liposome-encapsulated formulation of the mesylate salt form of eribulin, a synthetic,
macrocyclic ketone analogue of halichondrin B, a substance derived from the marine
sponge genus Halichondria, with potential antineoplastic activity. Eribulin binds
to the vinca domain of tubulin and inhibits both the polymerization of tubulin and
the assembly of microtubules. This results in the inhibition of mitotic spindle assembly,
the induction of cell cycle arrest at G2/M phase, as well as tumor cell apoptosis.
Compared to the administration of eribulin alone, liposomal delivery of eribulin allows
for a longer half-life, which allows increased drug concentration in target tissues
while decreasing systemic toxicity.;