Preferred Label : Donor Regulatory T-lymphocytes;
NCIt synonyms : Donor CD4 CD25 FoxP3 T Cells;
NCIt definition : Donor-derived regulatory T-cells (Tregs), with potential immunomodulating activity.
Tregs are a subset of CD4 T cells that express high levels of CD25 (interleukin 2
receptor) and the transcription factor Foxp3. The donor CD4 CD25 Tregs modulate immune
responses and may induce tolerance to allogeneic organ transplants, such as hematopoietic
stem cell transplants (HSCTs), thereby preventing graft-versus-host disease (GVHD).;
NCI Metathesaurus CUI : CL454227;
Origin ID : C111894;
UMLS CUI : C3830403;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
