Preferred Label : Oncolytic Herpes Simplex Virus-1-encoding GM-CSF;
NCIt synonyms : HSV-encoding GM-CSF; Recombinant hGM-CSF;
NCIt definition : An ICP34.5-, ICP47-deleted, oncolytic herpes simplex type-1 virus (HSV-1) isolated
from the mouth of an HSV-1-infected patient of Chinese Han ethnicity, and encoding
the immunostimulating factor cytokine granulocyte-macrophage colony stimulating factor
(GM-CSF) with potential immunostimulating and antineoplastic activities. Upon administration,
the recombinant human GM-CSF HSV-1 selectively infects and replicates in tumor cells,
thereby inducing tumor cell lysis. In addition, GM-CSF attracts dendritic cells (DCs)
and may stimulate a cytotoxic T cell response against tumor cells, which results in
immune-mediated tumor cell death. Deletion of the gene encoding for ICP34.5 provides
tumor selectivity and prevents replication in healthy cells. As ICP47 blocks antigen
presentation in HSV-infected cells, deletion of this gene may induce a more potent
antitumor immune response in the tumor cells. Additionally, deletion of ICP47 causes
increased expression of the HSV US11 gene and allows US11 to be expressed as an immediate
early and not a late gene. This further enhances the degree of viral replication and
oncolysis of tumor cells. Interruption of the ICP6 gene, which encodes the large subunit
of the viral ribonucleotide reductase, in the viral vector also enhances selective
replication in tumor cells.;
Drug name : OrienX010;
NCI Metathesaurus CUI : CL454226;
Origin ID : C111893;
UMLS CUI : C3828707;
Semantic type(s)
- Virus [UMLS semantic type]
- concept_is_in_subset
