Preferred Label : Ropeginterferon Alfa-2B;
NCIt synonyms : PEG-P-IFN-Alpha-2b; PEG-P-IFN-Alfa-2b; PEG-Proline-Interferon Alfa-2b;
NCIt definition : A long-acting formulation of recombinant interferon alpha subtype 2b (IFN-a2b), in
which IFN-a2b is coupled, via proline, to polyethylene glycol (PEG), with antiviral,
immunomodulating and antineoplastic activities. Upon administration of ropeginterferon
alfa-2b, IFN-a2b targets and binds to specific IFN cell-surface receptors. This activates
IFN-mediated signal transduction pathways and induces the transcription and translation
of genes with IFN-specific response elements (ISREs). Their protein products mediate
antiviral, antiproliferative, anticancer, and immune-modulating effects. The PEG moiety
inhibits proteolytic breakdown and clearance of IFN-a2b, which prolongs its half-life,
extends the duration of its therapeutic effects and allows less frequent dosing. The
proline linker facilitates the synthesis of a single positional isomer which further
increases its stability and half-life.;
UNII : 981TME683S;
CAS number : 1335098-50-4;
Drug name : Besremi;
Molecule name : AOP 2014; P-1101; AOP-2014;
Codes from synonyms : 453;
Origin ID : C111892;
UMLS CUI : C4542175;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- is_component_of_chemotherapy_regimen
