Preferred Label : Carbon C 14 Telotristat Etiprate;
NCIt synonyms : [14C]-LX1606; [14C]-telotristat Etiprate; 14C-telotristat Etiprate;
NCIt definition : An orally bioavailable, tryptophan hydroxylase (TPH) inhibitor prodrug labeled with
carbon C 14, which could be used to evaluate the pharmacokinetic profile of telotristat
etiprate. Upon administration, telotristat etiprate is converted to its active moiety,
telotristat (LP-778902), which binds to and blocks the activity of TPH. This may result
in a reduction in peripheral serotonin (5-HT) production and improvement of serotonin-mediated
gastrointestinal adverse side effects, such as severe diarrhea. TPH, the rate-limiting
enzyme in serotonin biosynthesis, is overexpressed in carcinoid tumor cells. Telotristat
radiolabeled with carbon C 14 facilitates the evaluation of the pharmacokinetic characteristics
of this agent, including its absorption, distribution, metabolism, and excretion (ADME).;
NCI Metathesaurus CUI : CL454225;
Origin ID : C111891;
UMLS CUI : C3831199;
Semantic type(s)
- concept_is_in_subset
