Preferred Label : Notch Receptor Intracellular Domain;
NCIt synonyms : Neurogenic Locus Notch Homolog Protein ICD; Neurogenic Locus Notch Homolog Protein Intracellular Domain; NICD; Notch ICD; Notch Intracellular Domain;
NCIt definition : The free carboxy-terminal intracellular domain (ICD) of a notch family protein, which
is a product of regulated intramembrane proteolysis mediated by the gamma-secretase
enzyme complex. This protein fragment is involved in transcriptional regulation of
target genes.;
NCIt note : Full-length notch proteins are post-translationally cleaved by furin to produce a
disulfide bound, two-chain protein that is expressed on the cell surface. Once a notch
ligand binds the extracellular portion, the larger amino-terminal portion is released
from the cell surface and the remaining portion of the receptor, termed the Notch
extracellular truncated (NEXT) domain is endocytosed. During endocytosis, NEXT is
cleaved sequentially by an ADAM family secretase followed by intramembrane cleavage
by gamma-secretase, which allows the notch intracellular domain to dissociate from
the membrane and translocate into the nucleus.;
Origin ID : C111794;
UMLS CUI : C3828777;
Semantic type(s)
- gene_product_plays_role_in_biological_process
