Preferred Label : Triptolide Analog;
NCIt related terms : MINNELIDE;
NCIt definition : A water soluble analog of the diterpenoid triepoxide triptolide isolated from the
Chinese herb Tripterygium wilfordii Hook.f., with potential antineoplastic activity.
Upon intravenous administration, the triptolide analog inhibits heat shock protein
70 (HSP70) and prevents HSP70-mediated inhibition of apoptosis. This leads to both
the induction of apoptosis and a reduction of cancer cell growth. HSP70, a molecular
chaperone upregulated in various cancer cells, plays a key role in the inhibition
of caspase-dependent and -independent apoptosis.;
UNII : 1CIV2UMO40;
CAS number : 1254702-87-8;
Drug name : Minnelide;
Origin ID : C111762;
UMLS CUI : C3827767;
Semantic type(s)
- concept_is_in_subset
- has_target
