Preferred Label : JAK Inhibitor INCB047986;
NCIt definition : An orally bioavailable inhibitor of Janus-associated kinases (JAK), with potential
antineoplastic activity. Upon oral administration, INCB047986 specifically binds to
and inhibits the phosphorylation of JAK, which affects JAK-dependent signaling and
may lead to an inhibition of cellular proliferation in JAK-overexpressing tumor cells.
The JAK-STAT (signal transducer and activator of transcription) pathway plays a key
role in the signaling of many cytokines and growth factors and is involved in cellular
proliferation, growth, hematopoiesis, and the immune response; JAK kinases may be
upregulated in inflammatory diseases, myeloproliferative disorders, and various malignancies.;
Molecule name : INCB 047986; INCB-047986;
NCI Metathesaurus CUI : CL454148;
Origin ID : C111761;
UMLS CUI : C3827109;
Semantic type(s)
- concept_is_in_subset
