Preferred Label : Mitochondrial Oxidative Phosphorylation Inhibitor ATR-101;
NCIt definition : An orally bioavailable inhibitor of mitochondrial oxidative phosphorylation with potential
antineoplastic activity. Upon administration, ATR-101 inhibits the activity of F1F0-ATP
synthase, elevates the mitochondrial membrane potential and depletes ATP in adrenocortical
cells. The mitochondrial dysfunction caused by the release of reactive oxygen and
triggered cytochrome c release leads to caspase-mediated cell death. ATR-101 may be
useful in treating certain types of adrenocortical carcinoma.;
NCI Metathesaurus CUI : CL454145;
Origin ID : C111758;
UMLS CUI : C4764315;
Semantic type(s)
- concept_is_in_subset
