Preferred Label : Mercaptopurine Oral Suspension;
NCIt synonyms : 6-MP Oral Suspension;
NCIt definition : An oral suspension containing the thiopurine-derivative antimetabolite 6-mercaptopurine,
with potential antineoplastic activity. Upon oral administration, mercaptopurine is
metabolized by hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) to its active
metabolite 6-thioinosine monophosphate (TIMP); TIMP inhibits nucleotide interconversions
and de novo purine ribonucleotide synthesis, which both blocks the formation of purine
nucleotides and inhibits DNA synthesis. This agent is also incorporated into DNA in
the form of deoxythioguanosine, which results in the disruption of DNA replication.
By blocking DNA synthesis and replication, cancer cells are unable to proliferate.
Compared to the tablet formulation, the liquid is easier to swallow and offers more
flexibility and accuracy in dosing, which is beneficial for use in pediatric patients.;
Drug name : Purixan; Xaluprine;
Origin ID : C111757;
UMLS CUI : C3820263;
Semantic type(s)
- concept_is_in_subset
