Preferred Label : HLA-A*0201 Restricted TERT(572Y)/TERT(572) Peptides Vaccine Vx-001;
NCIt synonyms : HLA-A*0201 Restricted Telomerase-specific Vaccine Vx-001;
NCIt definition : A peptide-based cancer vaccine consisting of two human leukocyte antigen (HLA)-A*0201
restricted 9-mer epitopes derived from the human telomerase reverse transcriptase
(hTERT), TERT 572Y (YLFFYRKSV; TYR-Vx001) and TERT 572 (RLFFYRKSV; ARG-Vx001), with
potential immunostimulating and antineoplastic activities. Subcutaneous injection
of TERT(572Y) peptide followed by subcutaneous administration of the TERT(572) peptide
may elicit a specific and possibly optimal cytotoxic T cell (CTL) response against
hTERT-expressing tumor cells. hTERT, the catalytic subunit of human telomerase, is
an human leukocyte antigen-A*0201-restricted cryptic epitope of telomerase. TERT is
expressed in the majority of human cancer cells, is not expressed or is expressed
at very low levels in normal cells and plays a key role in tumorigenesis. TERT572Y
is the optimized variant of the native cryptic peptide TERT572 in which tyrosine has
been substituted for an arginine at position 1; TERT572Y shows increased HLA-A*0201
binding affinity compared to TERT572.;
Molecule name : Vx-001;
Origin ID : C111689;
UMLS CUI : C1958472;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
