NCIt definition : A liposomal nanoparticle-based therapeutic vaccine composed of the cationic lipid
R-DOTAP (R-enantiomer of 1,2-dioleoyl-3-trimethylammonium-propane chloride) encapsulating
six human papillomavirus 16 (HPV-16) E6 and E7 peptides, with potential immunostimulating
activity. Upon subcutaneous administration of the liposomal HPV-16 E6 and E7 multipeptide
vaccine, the nanoparticles are taken up by antigen presenting cells (APCs), specifically
dendritic cells (DCs), which may stimulate the immune system to induce a cytotoxic
T-lymphocyte response (CTL) against HPV-16 E6 and E7-expressing tumor cells. HPV-16
E6 and E7 are oncoproteins that play a key role in the tumorigenesis of a variety
of cancers.;
Semantic type(s)