Preferred Label : Imisopasem Manganese;
NCIt synonyms : Manganese, dichloro[(4aR,13aR,17aR,21aR)-1,2,3,4,4a,5,6,12,13,13a,14,15,16,17,17a,18,19,20,21,21a-eicosahydro-11,7-nitrilo-7Hdibenzo[b,h][1,4,7,10]tetraazacycloheptadecine-kN5,kN13,kN18,kN21,kN22]-,
(PB-7-11-2344'3')-;
NCIt definition : A manganese-based non-peptidyl mimetic of the human mitochondrial manganese superoxide
dismutase (MnSOD), with potential antioxidant and chemo/radioprotective activities.
Upon administration, imisopasem manganese mimics the activity of MnSOD and scavenges
reactive oxygen species (ROS), such as superoxide anion, which prevents oxygen free
radical damage to macromolecules such as DNA. This reduces ROS-mediated lipid peroxidation,
prevents apoptosis and protects against oxygen free radical-induced toxicity in normal
tissues.;
UNII : 2Q6R3259KS;
InChIKey : WXEMWBBXVXHEPU-XNPJUPKFSA-L;
CAS number : 218791-21-0;
Molecule name : GC4403; M40403; SC-72325;
Origin ID : C111684;
UMLS CUI : C3502536;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
